The Antifungal Activity of Artesunate toward Candida albicans: Two Opposite Activities

MOHAMMAD RIZKI FADHIL PRATAMA, DARYONO HADI TJAHJONO, TUTUS GUSDINAR

Abstract


The artemisinin and its derivatives antifungal activity continue to be an interesting research object, with the potential shown to be developed as an antifungal compound. Artesunate, one of the artemisinin derivatives known to have antifungal activity against various pathogenic fungi, including Candida albicans. This study aims to determine the effect of artesunate on antifungal activity toward C. albicans in vitro at concentrations below 1 mgmL-1. The method used is yeast-plate count, with a parameter of observation were the number of C. albicans colonies viable after exposure with artesunate for five days. The concentration of artesunate used was divided into six groups, which were 10; 1; 10-1; 10-2; 10-3; and 10-4mgmL-1. Compared to control, a significant decrease in colony counts was only shown at the highest concentration of 10 mgmL-1. Interestingly, at the lowest concentration of 10-4mgmL-1, it showed an increase in a number of colonies almost twice of the blank. These results suggest that while at higher concentration of artesunate may inhibit the growth of C. albicans, a lower concentration of artesunate may stimulate their growth.


Keywords


artesunate; antiproliferative; Candida albicans



DOI: https://doi.org/10.5454/mi.13.3.%25p

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Content on this site is licensed under a Creative Commons Attribution 4.0 International Public License

 

Editorial Office and Publisher Address:

Indonesian Society for Microbiology (Secretariat PERMI), Gedung 110/SIDE OFFICE Lt.2 Ruang 01, Kawasan Puspiptek-Serpong, Tangerang Selatan 15314, Indonesia. Email: microbiology.indonesia@gmail.com