Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells

Authors

  • VIQQI KURNIANDA
  • SUCI FARADILLA
  • SOFYATUDDIN KARINA
  • SRI AGUSTINA
  • MARIA ULFAH
  • CHITRA OCTAVINA
  • FARAH SYAHLIZA
  • MUHAMMAD RIZKI RAMADHAN
  • SYAHRUL PURNAWAN
  • MUSRI MUSMAN

DOI:

https://doi.org/10.5454/mi.13.2.5

Keywords:

Callyspongia sp., isocopalane diterpene, human pancreatic cancer cells

Abstract

The bioactive compound from the Indonesian Marine SpongeCallyspongia sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]+ 412.576 m/z indicate that the compound has molecular formula C24H44O5 determined by LCMS-ESI. This compound has bioactivity IC50 = 0.1 μg / mL against human pancreatic cancer cell.

 

Published

2020-01-16

How to Cite

KURNIANDA, V., FARADILLA, S., KARINA, S., AGUSTINA, S., ULFAH, M., OCTAVINA, C., SYAHLIZA, F., RAMADHAN, M. R., PURNAWAN, S., & MUSMAN, M. (2020). Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells. Microbiology Indonesia, 13(2), 5. https://doi.org/10.5454/mi.13.2.5

Issue

Section

Articles