@article{UTAMI_WIDANARNI_SUPRAYUDI_2015, title={Administration of Microencapsulated Probiotic at Different Doses to Control Streptococcosis in Tilapia (Oreochromis niloticus)}, volume={9}, url={https://jurnal.permi.or.id/index.php/mionline/article/view/272}, DOI={10.5454/mi.9.1.3}, abstractNote={<p>This study aimed to produce microencapsulated probiotic and determine its optimal dose to control streptococcosis in tilapia (<em>Oreochromis niloticus</em>). The probiotic used in this study was <em>Bacillus </em>sp. NP5 RfR that was encapsulated by sterile 10% maltodextrin solution and dried by spray dryer. The experimental fish were reared 28 days and fed by the administration of microencapsulated probiotic in feed with different doses (0,5% (A), 1% (B), and 2% (C)) which were 10<sup>10</sup> CFU g<sup>-1</sup> as the concentration and control without administration of microencapsulated probiotic, including negative (K-) and positive (K+) control. On day 30, all of the fish except K- were challenged by injecting 0.1 mL/fish  of <em>Streptococcus agalactiae </em>(10<sup>5</sup> CFU ml<sup>-1</sup>) by intra-peritoneal (IP) route. This study showed that administration of 0.5% microencapsulated probiotic was effective to control streptococcosis in tilapia with higher post-challenge survival rate, better hematological parameter values, and could inhibit <em>S. agalactiae </em>growth in the host target organs.</p>}, number={1}, journal={Microbiology Indonesia}, author={UTAMI, DIAH AYU SATYARI and WIDANARNI, WIDANARNI - and SUPRAYUDI, M AGUS}, year={2015}, month={Mar.}, pages={3} }