@article{KURNIANDA_FARADILLA_KARINA_AGUSTINA_ULFAH_OCTAVINA_SYAHLIZA_RAMADHAN_PURNAWAN_MUSMAN_2020, title={Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells}, volume={13}, url={https://jurnal.permi.or.id/index.php/mionline/article/view/708}, DOI={10.5454/mi.13.2.5}, abstractNote={<p>The bioactive compound from the Indonesian Marine Sponge<em>Callyspongia </em>sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]<sup>+ </sup>412.576 m/z indicate that the compound has molecular formula C<sub>24</sub>H<sub>44</sub>O<sub>5</sub> determined by LCMS-ESI. This compound has bioactivity IC<sub>50</sub> = 0.1 μg / mL against human pancreatic cancer cell.</p><p> </p>}, number={2}, journal={Microbiology Indonesia}, author={KURNIANDA, VIQQI and FARADILLA, SUCI and KARINA, SOFYATUDDIN and AGUSTINA, SRI and ULFAH, MARIA and OCTAVINA, CHITRA and SYAHLIZA, FARAH and RAMADHAN, MUHAMMAD RIZKI and PURNAWAN, SYAHRUL and MUSMAN, MUSRI}, year={2020}, month={Jan.}, pages={5} }