@article{WIDJAJA_WINOTO_STURGIS_MAROEF_LISTIYANINGSIH_TAN_PAMUNGKAS_BLAIR_SAJUTHI_PORTER_2010, title={Macaca nemestrina and Dengue Virus Infectivity: a Potential Model for Evaluating Dengue Vaccine Candidates}, volume={4}, url={https://jurnal.permi.or.id/index.php/mionline/article/view/98}, DOI={10.5454/mi.4.2.1}, abstractNote={<p class="MsoNormal" style="margin: 5pt 11pt; tab-stops: 14.2pt;"><em style="mso-bidi-font-style: normal;"><span style="font-family: "Times New Roman","serif"; font-size: 8pt;">Macaca nemestrina</span></em><span style="font-family: "Times New Roman","serif"; font-size: 8pt;"> has been shown to respond to infectious disease agents, such as HIV, and is more sensitive compared to other species of macaques such as rhesus (<em style="mso-bidi-font-style: normal;">M. mulatta</em>) and cynomolgus monkeys (<em style="mso-bidi-font-style: normal;">M. fascicularis</em>).<span style="mso-spacerun: yes;">  </span>To evaluate <em style="mso-bidi-font-style: normal;">M. nemestrina</em> for the ability to support dengue (DEN) viremia and serve potentially as an improved model for testing DEN vaccines, a series of experiments were conducted using primary viral isolates from individuals with DEN virus infections.<span style="mso-spacerun: yes;">  </span>This study shows that <em style="mso-bidi-font-style: normal;">M. nemestrina</em> develops consistent, measurable viremia with all four DEN serotypes and produces immune responses sufficient to protect against homologous virus.<span style="mso-spacerun: yes;">  </span>Anti-dengue antibodies generated after infection are predominately IgG1.<span style="mso-spacerun: yes;">  </span>This species of monkey therefore appears to be a suitable model for testing DEN virus vaccine candidates.</span></p>}, number={2}, journal={Microbiology Indonesia}, author={WIDJAJA, SUSANA and WINOTO, IMELDA and STURGIS, JONATHAN and MAROEF, CHAIRIN N and LISTIYANINGSIH, ERLIN and TAN, RATNA and PAMUNGKAS, JOKO and BLAIR, PATRICK J and SAJUTHI, DONDIN and PORTER, KEVIN RANDALL}, year={2010}, month={Aug.}, pages={1} }