Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin

Authors

  • PRAPTIWI PRAPTIWI Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia
  • YULIASRI JAMAL Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia
  • AHMAD FATHONI Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia
  • ARIF NURKANTO Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia
  • ANDRIA AGUSTA Research Center for Biology, Indonesian Institute of Sciences, Jalan Raya Bogor 46, Cibinong, Indonesia

DOI:

https://doi.org/10.5454/mi.7.4.4

Keywords:

( )- 1, 1’-bislunatin, antibacterial, Diaporthe sp., effect on bacterial cells, endophytic fungus, GNBP-10, Uncaria gambier Roxb.

Abstract

Endophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Shigella flexneri, Proteus vulgaris, and P. mirabilis) with MIC value in the range of 

32-64 µg mL-1. The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article.

Published

2014-05-05

How to Cite

PRAPTIWI, P., JAMAL, Y., FATHONI, A., NURKANTO, A., & AGUSTA, A. (2014). Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin. Microbiology Indonesia, 7(4), 4. https://doi.org/10.5454/mi.7.4.4