Antibacterial Activity of Bisanthraquinone (+)-1,1’-Bislunatin
Keywords:( )- 1, 1’-bislunatin, antibacterial, Diaporthe sp., effect on bacterial cells, endophytic fungus, GNBP-10, Uncaria gambier Roxb.
AbstractEndophytic fungi has been known as a source of biologically active compunds with a broad sprectrum of activities. One of the endophytic fungi isolated from young stem of gambier plant (Uncaria gambier Roxb.:Rubiaceae), Diaporthe sp. GNBP-10, produced (+)-1,1’-bislunatin when cultivated on potato dextrose agar (PDA). (+)-1,1’-Bislunatin showed moderate antibacterial activity against 7 bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Micrococcus luteus, Shigella flexneri, Proteus vulgaris, and P. mirabilis) with MIC value in the range of
32-64 µg mL-1. The wall disruption and morphological changes in the cells affected by exposure of (+)-1,1’-bislunatin are also discussed in this article.